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  1. Today, the city is at the intersection of Interstates 81 and 90, and its airport is the largest in Central New York, a five-county region of over one million inhabitants. Syracuse is the economic and educational hub of Central New York.

  2. 18 apr. 2024 · Syracuse, city, city, seat (1827) of Onondaga county, central New York, U.S. It lies at the south end of Lake Onondaga, midway between Albany and Buffalo (147 miles [237 km] west). The site, once the territory of the Onondaga Indians and headquarters of the Iroquois Confederacy, was visited by.

    • The Editors of Encyclopaedia Britannica
  3. Downtown skyline with Onondaga Lake visible in the background. Syracuse is a city in Central New York. With a population of 149,000 in city proper and 662,000 in its metro area (2020), Syracuse is the fifth largest city in the state of New York, and the third largest in Upstate New York.